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Cancer is a leading cause of mortality in the United States. In 2021, 1,898,160 new cases and 608,570 deaths will occur in the United States. Increasing rates of cancer mortality in the United States occurred until 1991 but decreased through 2018 from its peak by 31%, with 3.2 million fewer cancer deaths in this period. However, these improvements are not equally applicable to all races, with significant differences in cancer mortality between Blacks and Whites. The 5-year relative survival rates for all cancers diagnosed between 2010-2016 were 68% (Whites) and 63 (Blacks), respectively. Disparities in cancer treatment, a major contributor to decreasing outcomes in cancer mortality, can be related to the underrepresentation of Blacks and other racial minorities in clinical trials.